One of the model's strongest Week 15 NFL picks is that the Jets (-1) cover the spread at home against the Lions. Now, it has turned its attention to the latest Week 15 NFL odds and locked in NFL picks for every NFL matchup. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks.

The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. All of the Week 15 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 15 NFL picks now. Other large Week 15 NFL betting lines include Eagles (-9) against the Bears and Packers (-7) against the Rams. The Kansas City Chiefs are the week's biggest favorites at -14.5 against the one-win Houston Texans in the NFL spreads. The latest Week 15 NFL odds from Caesars Sportsbook show the widening gap between the top contenders and the rest of the league.

As the Week 15 NFL schedule continues on Sunday, several teams are separating themselves as 2023 Super Bowl contenders.

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